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Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches

Samanta Cajic,René Hennig,Valerian Grote,Udo Reichl,Erdmann Rapp,

Engineering doi: 10.1016/j.eng.2023.02.016

Abstract: To fully delineate glycan structures, we developed an integrative approach combining a set of cost-effectiveThrough the detailed structural analysis of selected, dauntingly complex N-glycans from chicken ovalbuminMoreover, this approach “visualizes” N-glycans that have been difficult to identify thus far—such asthe sulfated glycans on human immunoglobulin A—including minute changes in glycan structures, potentially

Keywords： Glycoproteins     N-glycans     Reversible labeling     Hydrophilic interaction liquid chromatography     Capillary gel    

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Serum N-Glycan Markers for Diagnosing Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis Article

Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang

Engineering 2023, Volume 26, Issue 7,   Pages 151-158 doi: 10.1016/j.eng.2023.03.008

Abstract: Serum N-glycan profiles were tested using DNA sequencer-assisted fluorophore-assisted carbohydrateA total of nine N-glycan peaks were identified in serum samples for each subject.In distinguishing significant liver fibrosis, the diagnostic efficiency of the serum N-glycan/em>-glycan RF-A model compared with liver biopsy was 90.45%.In distinguishing liver cirrhosis, the diagnostic AUROC curve of the serum N-glycan RF model

Keywords： Liver fibrosis     Chronic hepatitis B     Serum N-glycan     N-glycan model     Alanine aminotransferase    

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Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 304-316 doi: 10.1007/s11684-022-0964-8

Abstract: The structure of N-glycans on specific proteins can regulate innate and adaptive immunity viaIn this work, we used THP-1-derived macrophages as examples to show the vast potential of a N-glycan structural interpretation tool StrucGP in N-glycoproteomic analysis.spectrometry (MS)-based glycoproteomic approaches, followed by the large-scale mapping of site-specific glycan, and sialylated glycans (e.g., HexNAc4Hex5Fuc1Neu5Ac1, N<

Keywords： macrophage     glycoproteome     glycopeptides     N-glycan structures     PD-L1    

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Removable Dyes—The Missing Link for In-Depth N-Glycan Analysis via Multi-Method Approaches Article

Samanta Cajic, René Hennig, Valerian Grote, Udo Reichl, Erdmann Rapp

Engineering 2023, Volume 26, Issue 7,   Pages 132-150 doi: https://doi.org/10.1016/j.eng.2023.02.016

Abstract: To fully delineate glycan structures, we developed an integrative approach combining a set of cost-effectiveThrough the detailed structural analysis of selected, dauntingly complex N-glycans from chickenMoreover, this approach "visualizes" N-glycans that have been difficult to identifyfar—such as the sulfated glycans on human immunoglobulin A—including minute changes in glycan

Keywords： Glycoproteins     N-glycans     Reversible labeling     Hydrophilic interaction liquid chromatography     Capillary    

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Applicability of high dimensional model representation correlations for ignition delay times of n-heptane

Wang LIU, Jiabo ZHANG, Zhen HUANG, Dong HAN

Frontiers in Energy 2019, Volume 13, Issue 2,   Pages 367-376 doi: 10.1007/s11708-018-0584-9

Abstract: In this paper, the random sampling-high dimensional model representation (RS-HDMR) methods were employedto predict the ignition delay times of n-heptane/air mixtures, which exhibits the NTC phenomenon, overA detailed n-heptane chemical mechanism was used to calculate the fuel ignition delay times in the adiabaticcorrelations had a satisfactory prediction accuracy in general for the ignition delay times of the n-heptane

Keywords： ignition delay     random sampling     high dimensional model representation     n-heptane     fuel kinetics    

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Shear-flexural strength mechanical model for the design and assessment of reinforced concrete beams subjected

Antonio MARÍ,Antoni CLADERA,Jesús BAIRÁN,Eva OLLER,Carlos RIBAS

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4,   Pages 337-353 doi: 10.1007/s11709-014-0081-0

Abstract: A mechanical model recently developed for the shear strength of slender reinforced concrete beams withThe predictions of the model have been compared to those obtained by using the EC2, MC2010 and ACI 318

Keywords： shear strength     mechanical model     reinforced concrete     design     assessment     shear tests    

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Coupling the porous conditional moment closure with the random pore model: applications to gasification

N. SAULOV, C. R. CHODANKA, M. J. CLEARY, A. Y. KLIMENKO

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 1,   Pages 84-93 doi: 10.1007/s11705-011-1164-2

Abstract: Therefore, the development of a comprehensive, physically-based gasifier model is important.sorbent material are among the key sub-models, which provide a necessary input for an overall gasifier modelThe porous conditional moment closure (PCMC) model proves to be adequate for modeling reactive transportSuch changes are not taken into account in the existing PCMC model.diffusive tracer distribution based on the pore size distribution given by the widely applied random pore model

Keywords： gasification     CO2 capture     PCMC     RPM    

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Effect of 2,5-dimethylfuran addition on ignition delay times of n-heptane at high temperatures

Zhenhua GAO, Erjiang HU, Zhaohua XU, Geyuan YIN, Zuohua HUANG

Frontiers in Energy 2019, Volume 13, Issue 3,   Pages 464-473 doi: 10.1007/s11708-019-0609-z

Abstract: The shock tube autoignition of 2,5-dimethylfuran (DMF)/n-heptane blends (DMF0-100%, by mole fraction)A detailed blend chemical kinetic model resulting from the merging of validated kinetic models for theAs the DMF addition increases to relatively higher levels, the consumption path of n-heptane is significantlysmall radicals, which primarily leads to the nonlinear increase in the ignition delay times of DMF/n-heptane

Keywords： ignition delay time     shock tube     kinetic model     2     5-dimethylfuran (DMF)     n-heptane    

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Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus Article

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Engineering 2023, Volume 26, Issue 7,   Pages 89-98 doi: 10.1016/j.eng.2023.01.006

Abstract: Here, we identified two N-glycans on serum immunoglobulin G (IgG) as excellent diagnostic biomarkersThese two N-glycan biomarkers are specific for diagnosing SLE, as no significant changes inNotably, the two N-glycan biomarkers proved to be autoantibody-independent and all-stage patientThe two N-glycan biomarkers are demonstrated to be located on the Fc region based on fragment-specificglycan analysis and glycopeptide analysis, suggesting their close correlation with disease activity.

Keywords： Systemic lupus erythematosus     N-glycans     Diagnostic indicators    

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Development of a simplified n-heptane/methane model for high-pressure direct-injection natural

Jingrui LI, Haifeng LIU, Xinlei LIU, Ying YE, Hu WANG, Xinyan WANG, Hua ZHAO, Mingfa YAO

Frontiers in Energy 2021, Volume 15, Issue 2,   Pages 405-420 doi: 10.1007/s11708-021-0718-3

Abstract: In the present paper, a reduced -heptane/methane model consisting of 35-step reactions was constructedThen this model was further reduced to include only 27 reactions by utilizing the HyChem (Hybrid Chemistryachieved and reasonable predictions for the measured laminar flame speeds were obtained for the 35-step modelBut the 27-step model cannot predict the laminar flame speed very well., the predicted distributions of OH and CH O are significantly different from those of the 334-step model

Keywords： high-pressure direct-injection     natural gas     chemical kinetics     combustion modelling     marine engine    

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Cyclic stress-strain behavior of structural steel with yield-strength up to 460 N/mm

Yiyi CHEN,Wei SUN,Tak-Ming CHAN

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 2,   Pages 178-186 doi: 10.1007/s11709-014-0245-y

Abstract: This paper presents a constitutive model based on Ramberg-Osgood equation to describe the hysteresismaterial behavior of structural carbon steel with nominal yield strength between 235 to 420 N/mm .The proposed model was calibrated against a series of cyclic material tests with strain amplitude varyingfurther the experimental behavior of test specimens with nominal yield strength of 460 N/mm .The proposed constitutive model was also adopted in conjunction with the combined kinematic/isotropic

Keywords： constitutive model     finite element analysis     hysteresis curve     Ramberg-Osgood equation    

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Mathematical model and manufacture programming of loxodromic-type normal circular-arc spiral bevel gear

Zhenyun DUAN, Houjun CHEN, Zhilan JU, Jian LIU

Frontiers of Mechanical Engineering 2012, Volume 7, Issue 3,   Pages 312-321 doi: 10.1007/s11465-012-0308-5

Abstract: Based on the principle of molding-surface conjugation, the study develops a mathematical model for the

Keywords： loxodrome     circular-arc tooth profile     Wildhaber-Novikov (W-N) gear     spiral bevel gear    

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Optimal design and development of PV-wind-battery based nano-grid system: A field-on-laboratory demonstration

MANDAL, N. CHAKRABORTY

Frontiers in Energy 2019, Volume 13, Issue 2,   Pages 269-283 doi: 10.1007/s11708-018-0573-z

Abstract: Initially, a prefeasibility study is conducted using the well-established HOMER (hybrid optimization model

Keywords： photovoltaic (PV)     wind     battery     nano-grid     hybrid optimization model for electric renewable (HOMER)     field-on-lab    

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Clinical applications of neurolinguistics in neurosurgery

Peng Wang, Zehao Zhao, Linghao Bu, Nijiati Kudulaiti, Qiao Shan, Yuyao Zhou, N. U.

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 562-574 doi: 10.1007/s11684-020-0771-z

Abstract: The protection of language function is one of the major challenges of brain surgery. Over the past century, neurosurgeons have attempted to seek the optimal strategy for the preoperative and intraoperative identification of language-related brain regions. Neurosurgeons have investigated the neural mechanism of language, developed neurolinguistics theory, and provided unique evidence to further understand the neural basis of language functions by using intraoperative cortical and subcortical electrical stimulation. With the emergence of modern neuroscience techniques and dramatic advances in language models over the last 25 years, novel language mapping methods have been applied in the neurosurgical practice to help neurosurgeons protect the brain and reduce morbidity. The rapid advancements in brain–computer interface have provided the perfect platform for the combination of neurosurgery and neurolinguistics. In this review, the history of neurolinguistics models, advancements in modern technology, role of neurosurgery in language mapping, and modern language mapping methods (including noninvasive neuroimaging techniques and invasive cortical electroencephalogram) are presented.

Keywords： neurolinguistics     language mapping     dual pathway model     neurosurgery    

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Mechanistic insight into the biofilm formation and process performance of a passive aeration ditch (PAD) for decentralized wastewater treatment

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1494-3

Abstract:

• A Passive Aeration Ditch was developed to treat decentralized wastewater.

Keywords： Decentralized wastewater     Passive aeration ditch     Biofilm formation     C/N ratio     Salinity     Model simulation    

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Title Author Date Type Operation

Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches

Samanta Cajic,René Hennig,Valerian Grote,Udo Reichl,Erdmann Rapp,

Journal Article

Serum N-Glycan Markers for Diagnosing Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis

Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang

Journal Article

Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Journal Article

Removable Dyes—The Missing Link for In-Depth N-Glycan Analysis via Multi-Method Approaches

Samanta Cajic, René Hennig, Valerian Grote, Udo Reichl, Erdmann Rapp

Journal Article

Applicability of high dimensional model representation correlations for ignition delay times of n-heptane

Wang LIU, Jiabo ZHANG, Zhen HUANG, Dong HAN

Journal Article

Shear-flexural strength mechanical model for the design and assessment of reinforced concrete beams subjected

Antonio MARÍ,Antoni CLADERA,Jesús BAIRÁN,Eva OLLER,Carlos RIBAS

Journal Article

Coupling the porous conditional moment closure with the random pore model: applications to gasification

N. SAULOV, C. R. CHODANKA, M. J. CLEARY, A. Y. KLIMENKO

Journal Article

Effect of 2,5-dimethylfuran addition on ignition delay times of n-heptane at high temperatures

Zhenhua GAO, Erjiang HU, Zhaohua XU, Geyuan YIN, Zuohua HUANG

Journal Article

Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Journal Article

Development of a simplified n-heptane/methane model for high-pressure direct-injection natural

Jingrui LI, Haifeng LIU, Xinlei LIU, Ying YE, Hu WANG, Xinyan WANG, Hua ZHAO, Mingfa YAO

Journal Article

Cyclic stress-strain behavior of structural steel with yield-strength up to 460 N/mm

Yiyi CHEN,Wei SUN,Tak-Ming CHAN

Journal Article

Mathematical model and manufacture programming of loxodromic-type normal circular-arc spiral bevel gear

Zhenyun DUAN, Houjun CHEN, Zhilan JU, Jian LIU

Journal Article

Optimal design and development of PV-wind-battery based nano-grid system: A field-on-laboratory demonstration

MANDAL, N. CHAKRABORTY

Journal Article

Clinical applications of neurolinguistics in neurosurgery

Peng Wang, Zehao Zhao, Linghao Bu, Nijiati Kudulaiti, Qiao Shan, Yuyao Zhou, N. U.

Journal Article

Mechanistic insight into the biofilm formation and process performance of a passive aeration ditch (PAD) for decentralized wastewater treatment

Journal Article